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PHOSPHORYLATED CARDIAC MYOSIN BINDING PROTEIN-C ENHANCES LUSITROPY
- Source :
- Journal of the American College of Cardiology. (12):A871
- Publisher :
- American College of Cardiology Foundation. Published by Elsevier Inc.
-
Abstract
- Cardiac myosin binding protein-C (MyBPC3) releases its inhibition on cross-bridge cycling when phosphorylated. Thus, we hypothesize that phosphorylated MyBPC3 enhances relaxation to mediate diastolic function as underlying mechanism and potential treatment for heart failure with preserved ejection
Details
- Language :
- English
- ISSN :
- 07351097
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....420d5e4496e1c6c21375e80ad707bfac
- Full Text :
- https://doi.org/10.1016/S0735-1097(14)60871-8