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Serum Carcinoembryonic Antigen in Relation to Survival, DNA Ploidy Pattern, and Recurrent Disease in 406 Colorectal Carcinoma Patients
- Source :
- Scandinavian Journal of Gastroenterology. 27:1061-1068
- Publication Year :
- 1992
- Publisher :
- Informa UK Limited, 1992.
-
Abstract
- Serum carcinoembryonic antigen (CEA) levels in relation to survival, flow cytometric DNA ploidy pattern, Dukes stage, and recurrent disease was prospectively evaluated in 406 patients with colorectal carcinoma. In 246 patients (61%) the carcinomas were DNA aneuploid. Increased preoperative CEA levels (> 5 micrograms/l) were found in 151 of 363 evaluable patients (42%). Dukes stage-B patients with preoperative CEA elevation showed significantly poorer prognosis than those with normal CEA values (p = 0.001). A weak but significant correlation was found between preoperative CEA level and Dukes stage (Kendall's tau = 0.25, p < 0.01). Of 50 evaluable patients with clinical recurrence and postoperative normal or normalized CEA levels, 28 (56%) had a rise in CEA before or at the time of clinical recurrence. The sensitivity of the CEA test for primary and for recurrent disease was not significantly different in the DNA aneuploid and the DNA near-diploid groups.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Colorectal cancer
Microgram
Rectum
Adenocarcinoma
Gastroenterology
Carcinoembryonic antigen
Internal medicine
medicine
Carcinoma
Humans
neoplasms
Survival rate
Aged
Ploidies
biology
Epithelioma
business.industry
DNA, Neoplasm
Middle Aged
medicine.disease
digestive system diseases
Carcinoembryonic Antigen
Survival Rate
medicine.anatomical_structure
biology.protein
Female
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 15027708 and 00365521
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....42085369853909e0cbfcf7a2951ea3c4