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Cholesterol – the devil you know; ceramide – the devil you don’t
- Source :
- Trends Pharmacol Sci
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely used clinical biomarker of cardiovascular disease and a target of pharmacological interventions (e.g., statins). Thousands of studies have interrogated the regulation and action of this disease-causing sterol. As a growing body of literature indicates, a new class of lipid-based therapies may be on the horizon. Ceramides are cholesterol-independent biomarkers of heart disease and diabetes in humans. Studies in rodents suggest that they are causative agents of disease, as lowering ceramides through genetic or pharmacological interventions prevents cardiovascular disease and diabetes. Herein, we discuss the evidence supporting the potential of therapeutics targeting ceramides to treat cardiometabolic disease, contrasting it with the robust datasets that drove the creation of cholesterol-lowering pharmaceuticals.
- Subjects :
- Pharmacology
Ceramide
Heart Diseases
Heart disease
Cholesterol
business.industry
Disease
Ceramides
Toxicology
medicine.disease
Bioinformatics
Article
chemistry.chemical_compound
chemistry
Lipotoxicity
Cardiovascular Diseases
Diabetes mellitus
Hyperlipidemia
medicine
Humans
lipids (amino acids, peptides, and proteins)
business
Stroke
Biomarkers
Subjects
Details
- ISSN :
- 01656147
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Trends in Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....4205fc113fbeea78b36e2942838623e0