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Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs
- Source :
- Peptides. 12:499-502
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Hemodynamics
In Vitro Techniques
Biology
Biochemistry
Pancreastatin
Cellular and Molecular Neuroscience
Dogs
Endocrinology
In vivo
Internal medicine
medicine
Animals
Humans
Endocrine system
Amylase
Pancreas
Pancreatic hormone
Cholecystokinin
Proteins
Rats, Inbred Strains
Pancreatic Hormones
Peptide Fragments
Recombinant Proteins
Rats
Gastrointestinal hormone
Regional Blood Flow
Amylases
biology.protein
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....4205c68b775c955eceb9b029d328eba8