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‘Artemisinin Resistance’: Something New or Old? Something of a Misnomer?
- Source :
- Trends in Parasitology. 36:735-744
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Artemisinin and its derivatives (ART) are crucial first-line antimalarial drugs that rapidly clear parasitemia, but recrudescences of the infection frequently follow ART monotherapy. For this reason, ART must be used in combination with one or more partner drugs that ensure complete cure. The ability of malaria parasites to survive ART monotherapy may relate to an innate growth bistability phenomenon whereby a fraction of the drug-exposed population enters into metabolic quiescence (dormancy) as persister forms. Characterization of the events that underlie entry and waking from persistence may lead to lasting breakthroughs in malaria chemotherapy that can prevent recrudescences and protect the future of ART-based combination therapies.
- Subjects :
- 0301 basic medicine
Plasmodium
medicine.medical_specialty
030231 tropical medicine
Population
Drug Resistance
Misnomer
Parasitemia
Antimalarials
03 medical and health sciences
0302 clinical medicine
Recurrence
parasitic diseases
medicine
Humans
Artemisinin
education
Intensive care medicine
education.field_of_study
business.industry
Artemisinin resistance
medicine.disease
Artemisinins
030104 developmental biology
Infectious Diseases
Parasitology
business
Malaria
medicine.drug
Subjects
Details
- ISSN :
- 14714922
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Trends in Parasitology
- Accession number :
- edsair.doi.dedup.....41ff7a09c2afbada5a95b741e701363f