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Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease
Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease
- Source :
- Van Dijk, K R A, Luijpen, M W, Van Someren, E J W, Sergeant, J A, Scheltens, P & Scherder, E J A 2006, ' Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease ', Journal of Sleep Research, vol. 15, no. 4, pp. 415-423 . https://doi.org/10.1111/j.1365-2869.2006.00548.x, van Dijk, K R A, Luijpen, M W, van Someren, E J W, Sergeant, J A, Scheltens, P & Scherder, E J A 2006, ' Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease ', Journal of Sleep Research, vol. 15, no. 4, pp. 415-423 . https://doi.org/10.1111/j.1365-2869.2006.00548.x, Journal of Sleep Research, 15, 415-423. Wiley, Journal of Sleep Research, 15(4), 415-423. Wiley-Blackwell, Journal of Sleep Research, 15(4), 415-423. Wiley
- Publication Year :
- 2006
-
Abstract
- Rest-activity rhythm disruption is a prominent clinical feature of Alzheimer's disease (AD). The origin of the altered rest-activity rhythm is believed to be degeneration of the suprachiasmatic nucleus (SCN). In accordance with the 'use it or lose it' hypothesis of Swaab [Neurobiol Aging 1991, 12: 317-324] stimulation of the SCN may prevent age-related loss of neurons and might reactivate nerve cells that are inactive but not lost. Previous studies with relatively small sample sizes have demonstrated positive effects of peripheral electrical nerve stimulation on the rest-activity rhythm in AD patients. The present randomized, placebo-controlled, parallel-group study was meant to replicate prior findings of electrical stimulation in AD in a substantially larger group of AD patients. The experimental group (n = 31) received peripheral electrical nerve stimulation and the placebo group (n = 31) received sham stimulation. Effects of the intervention on the rest-activity rhythm were assessed by using wrist-worn actigraphs. Near-significant findings on the rest-activity rhythm partially support the hypothesis that neuronal stimulation enhances the rest-activity rhythm in AD patients. Interestingly, post-hoc analyses revealed significant treatment effects in a group of patients who were not using acetylcholinesterase inhibitors concomitantly. We conclude that more research is needed before firm general conclusions about the effectiveness of electrical stimulation as a symptomatic treatment in AD can be drawn. In addition, the present post-hoc findings indicate that future studies on non-pharmacological interventions should take medication use into account. © 2006 European Sleep Research Society.
- Subjects :
- Activity Cycles
Male
Stimulation
law.invention
Behavioral Neuroscience
transcutaneous electrical nerve stimulation
law
ACTIGRAPHY
SLEEP DISTURBANCE
Aged, 80 and over
Neurons
Sleep disorder
Suprachiasmatic nucleus
DEMENTIA
Brain
General Medicine
Middle Aged
SUPRACHIASMATIC NUCLEUS
Peripheral
Treatment Outcome
Transcutaneous Electric Nerve Stimulation
alzheimer's disease
Female
CIRCADIAN-RHYTHMS
circadian rhythm
NURSING-HOME PATIENTS
medicine.medical_specialty
Cognitive Neuroscience
CONTROLLED-TRIAL
Transcutaneous electrical nerve stimulation
Rhythm
SDG 3 - Good Health and Well-being
Alzheimer Disease
Internal medicine
medicine
Dementia
Humans
Circadian rhythm
Peripheral Nerves
Aged
Afferent Pathways
business.industry
medicine.disease
TENS IMPROVES
Endocrinology
RAT
rest-activity rhythm
business
Mental Status Schedule
BRIGHT LIGHT TREATMENT
Subjects
Details
- Language :
- English
- ISSN :
- 09621105
- Database :
- OpenAIRE
- Journal :
- Van Dijk, K R A, Luijpen, M W, Van Someren, E J W, Sergeant, J A, Scheltens, P & Scherder, E J A 2006, ' Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease ', Journal of Sleep Research, vol. 15, no. 4, pp. 415-423 . https://doi.org/10.1111/j.1365-2869.2006.00548.x, van Dijk, K R A, Luijpen, M W, van Someren, E J W, Sergeant, J A, Scheltens, P & Scherder, E J A 2006, ' Peripheral electrical nerve stimulation and rest-activity rhythm in Alzheimer's disease ', Journal of Sleep Research, vol. 15, no. 4, pp. 415-423 . https://doi.org/10.1111/j.1365-2869.2006.00548.x, Journal of Sleep Research, 15, 415-423. Wiley, Journal of Sleep Research, 15(4), 415-423. Wiley-Blackwell, Journal of Sleep Research, 15(4), 415-423. Wiley
- Accession number :
- edsair.doi.dedup.....41ff4b89db017b9c4ba7e6e7bd64d0d6
- Full Text :
- https://doi.org/10.1111/j.1365-2869.2006.00548.x