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Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters
- Source :
- Appetite. 59(1)
- Publication Year :
- 2011
-
Abstract
- The dopamine D(3) receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D(3) receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D(3) receptor manipulation does not modulate brain responses to food images in overweight and obese subjects.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
media_common.quotation_subject
Striatum
Overweight
Amygdala
Young Adult
Double-Blind Method
Reward
Dopamine receptor D3
Dopamine
Internal medicine
medicine
Humans
Obesity
General Psychology
media_common
Cerebral Cortex
Nutrition and Dietetics
Cross-Over Studies
medicine.diagnostic_test
Addiction
digestive, oral, and skin physiology
Receptors, Dopamine D3
Middle Aged
Magnetic Resonance Imaging
Corpus Striatum
Endocrinology
medicine.anatomical_structure
Female
medicine.symptom
Psychology
Functional magnetic resonance imaging
Insula
Neuroscience
Binge-Eating Disorder
medicine.drug
Subjects
Details
- ISSN :
- 10958304
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Appetite
- Accession number :
- edsair.doi.dedup.....41fc6a9bb0421b8af33075fca6f23288