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Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris
- Source :
- Bioorganic & Medicinal Chemistry Letters. 26:4966-4969
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Columnaristerol A ( 1 ), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris , and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia–lymphoma cell lines.
- Subjects :
- Proton Magnetic Resonance Spectroscopy
Clinical Biochemistry
Taiwan
Pharmaceutical Science
Biology
01 natural sciences
Biochemistry
Columnaris
Microbiology
Structure-Activity Relationship
Cell Line, Tumor
hemic and lymphatic diseases
Drug Discovery
medicine
Animals
Humans
Carbon-13 Magnetic Resonance Spectroscopy
Molecular Biology
010405 organic chemistry
Ecology
Organic Chemistry
Anthozoa
medicine.disease
Sterol
0104 chemical sciences
Sterols
010404 medicinal & biomolecular chemistry
Molecular Medicine
Drug Screening Assays, Antitumor
Norsteroids
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....41fa44d44d39399e6f381de790078999
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.09.007