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Supplementary File from Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery

Authors :
Barbara S. Slusher
Michael Polydefkis
Guido Cavaletti
Stuart C. Feinstein
Mary A. Jordan
Leslie Wilson
Christopher DesJardins
Sean Eckley
Krista Condon
Kenichi Nomoto
Bruce A. Littlefield
Brett M. Cook
Sara Semperboni
Eleonora Pozzi
Paola Alberti
Elisa Ballarini
Virginia Rodriguez-Menendez
Valentina A. Carozzi
Ying Liu
Ying Wu
James J. Vornov
Krystyna M. Wozniak
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

File contains description of supplementary methods used for sciatic nerve immunofluorescence data generation and quantification with Supplementary Fig 1 showing how raw fluorescence intensity values were normalized in order to compare levels of acetylated alpha tubulin from samples across treatment groups. Supplementary Figs 2 thru 4 show DRG and sciatic nerve morphology/morphometrics for chemotherapies other than PACLI. Supplementary Table 1 adds perspective to how MTD used to compare the chemotherapies in this study relates to their pharmacokinetic and IC50 properties.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....41c8fe14a2eaf120d0d4176f58a513a6
Full Text :
https://doi.org/10.1158/0008-5472.22417085