Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians

Authors :: Ana Hatagima
Maria de Nazaré Klautau-Guimarães
Cássia de Oliveira Hiragi
Iris Ferrari
Renata Ferreira D'Ascenção
Cesar Koppe Grisolia
Silviene Fabiana de Oliveira
Source :: Genetics and Molecular Biology, Vol 28, Iss 1, Pp 32-35 (2005), Genetics and Molecular Biology v.28 n.1 2005, Genetics and Molecular Biology, Sociedade Brasileira de Genética (SBG), instacron:SBG, Repositório Institucional da UnB, Universidade de Brasília (UnB), instacron:UNB, Genetics and Molecular Biology, Volume: 28, Issue: 1, Pages: 32-35, Published: MAR 2005
Publication Year :: 2005
Publisher :: Sociedade Brasileira de Genética, 2005.
Abstract: The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missao Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0% for GSTM1 and 27% for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27% for GSTM1 and 29% for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.

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