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CEREBRAL VENOUS SINUS THROMBOSIS IN PATIENTS WITH METASTATIC TESTICULAR CANCER DURING CHEMOTHERAPY: REPORTS OF TWO CASES
- Source :
- The Japanese Journal of Urology. 108:225-228
- Publication Year :
- 2017
- Publisher :
- Japanese Urological Association, 2017.
-
Abstract
- Cerebral venous sinus thrombosis (CVT) is rare but sometimes develops in association with malignant neoplasm. We report two cases of CVT that occurred during cisplatin-based chemotherapy for testicular cancer. A 46-year-old man with stage IIA non-seminomatous germ cell tumour was treated with conventional doses of etoposide and cisplatin (EP). On day 11 of the third treatment course, he developed a systemic seizure. Brain computed tomography (CT) and magnetic resonance (MR) imaging could not detect the cause. Enhanced chest-pelvic CT revealed pelvic thrombosis. Administration of phenytoin for epilepsy of unknown cause and heparin for thrombosis was started. He had completed 4 courses of EP therapy without seizure recurrence. After re-evaluating the brain CT images retrospectively, we found high density of superior sagittal sinus (SSS) and strongly suspected CVT. Another patient was a 47-year-old man with stage IIIB seminomatous germ cell tumour treated with bleomycin, etoposide, and cisplatin (BEP) therapy. On day 11 of the second treatment course, he developed a systemic seizure. Brain CT revealed subarachnoid haemorrhage localised in the right parietal lobe. CT venography revealed a filling defect in the superior sagittal sinus (SSS). MR venography revealed a SSS stenosis. We diagnosed the cause of the seizure as CVT and started administration of anticoagulant therapy. After the thrombus had diminished, chemotherapy was restarted and another 2 courses of BEP therapy was completed.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Chemotherapy
medicine.diagnostic_test
business.industry
Urology
medicine.medical_treatment
Magnetic resonance imaging
030105 genetics & heredity
medicine.disease
Thrombosis
03 medical and health sciences
0302 clinical medicine
medicine
Radiology
Thrombus
Cerebral venous sinus thrombosis
business
030217 neurology & neurosurgery
Etoposide
Testicular cancer
Superior sagittal sinus
medicine.drug
Subjects
Details
- ISSN :
- 18847110 and 00215287
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- The Japanese Journal of Urology
- Accession number :
- edsair.doi.dedup.....41c6dd6b000a4b686ee56240dc560fd2