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Alterins Produced by Oyster-Associated Pseudoalteromonas Are Antibacterial Cyclolipopeptides with LPS-Binding Activity
- Source :
- Marine Drugs, Vol 18, Iss 630, p 630 (2020), Marine Drugs, Volume 18, Issue 12, Marine drugs, Marine drugs, MDPI, 2020, 18 (12), ⟨10.3390/md18120630⟩, Marine drugs, 2020, 18 (12), ⟨10.3390/md18120630⟩, Marine Drugs (1660-3397) (MDPI AG), 2020-12, Vol. 18, N. 12, P. 630 (16p.)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Discovery after discovery, host-associated microbiota reveal a growing list of positive effects on host homeostasis by contributing to host nutrition, improving hosts' immune systems and protecting hosts against pathogens. In that context, a collection of oyster associated bacteria producing antibacterial compounds have been established to evaluate their role in non-host-derived immunity. Here, we described alterins<br />potent anti-Gram negative compounds produced by Pseudoalteromonas hCg-6 and hCg-42 isolated from different healthy oyster hemolymph. The strains hCg-6 and hCg-42 produce a set of at least seven antibacterial compounds, ranging from 926 to 982 Da structurally characterized as cyclolipopeptides (CLPs). Alterins share the same cationic heptapeptidic cycle connected via an amido bond to different hydrophobic hydrocarbon tails. Their MICs disclosed a potent antibacterial activity directed against Gram-negative bacteria including oyster and human pathogens that may confer a beneficial defense mechanism to the host but also represents an untapped source of new antibiotics. The alterins&rsquo<br />mechanisms of action have been deciphered: after binding to lipopolysaccharides (LPS), alterins provoke a membrane depolarization and permeabilization leading to bacterial lysis. As hCg-6 and hCg-42 produced a set of natural derivatives, the structure/activity relationship linked to the carbon tail is clarified. We showed that the hydrocarbon tail determines the LPS-binding properties of alterins and consequently their antibacterial activities. Its length and saturation seem to play a major role in this interaction.
- Subjects :
- Oyster
Pharmaceutical Science
Human pathogen
Context (language use)
Microbiology
03 medical and health sciences
Pseudoalteromonas
Immune system
antibiotic
biology.animal
Drug Discovery
Hemolymph
[SDV.BID.EVO] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
030304 developmental biology
cyclolipopeptides
0303 health sciences
biology
030306 microbiology
Chemistry
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
biology.organism_classification
lcsh:Biology (General)
bacteria
Antibacterial activity
alterin
Bacteria
Subjects
Details
- ISSN :
- 16603397
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....41c6ab7823e22fa313a3a38a7a1792b2