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Characterization and comparison of imaging contrast enhancement with PEG-functionalized gold nanoparticles in kV cone beam computed tomography and computed tomography imaging
- Source :
- Biomed Phys Eng Express
- Publication Year :
- 2020
- Publisher :
- IOP Publishing, 2020.
-
Abstract
- The purpose of this study is to define a simplified method to accurately predict and characterize kV cone beam computed tomography (kV CBCT) and computed tomography (CT) image contrast enhancement from gold nanoparticles (GNPs). Parameters of the kV CBCT of a Varian Novalis Tx linear accelerator and of a GE LightSpeed 4 Big Bore CT machine were modeled using the MCNP 6.2 Monte Carlo code. A 0.25 × 0.25 cm(2) source, defined with a 100 kVp energy spectrum with appropriate filtration, was implemented in the MCNP6.2 model for kV CBCT, which also contained x- and y-blades and a full bowtie filter. A 1 cm(3) cube of GNP solution (modeled as a mass percentage of gold in water) was placed 100 cm below the source. For the CT-simulator model, a source was defined with energy spectra for 80 and 140 kVp x-rays with appropriate filtration and angular spectrum. A 1 cm(3) GNP solution was modeled as before and a detector was placed 40 cm below that. Attenuation coefficients of four GNP solutions were computed and Hounsfield unit (HU) values were calculated. The computed HU values were compared against experimentally measured values obtained by scanning batches of GNPs of various sizes and concentrations using a GE LightSpeed 4 Big Bore CT scanner at 80 kVp and 140 kVp energies, as well as the kV CBCT capability of a Varian Novalis Tx linear accelerator. HU analysis was carried out using Velocity Medical Solutions clinical CT image analysis software. The MCNP calculated HU values matched the measured values to within ± 5%. Image contrast enhancement analysis showed a total increase in HU of up to 223. The sample having the highest gold mass percentage tested showed the greatest increase in HU number compared to water.
- Subjects :
- Scanner
Cone beam computed tomography
Tomography Scanners, X-Ray Computed
Materials science
0206 medical engineering
Contrast Media
Metal Nanoparticles
02 engineering and technology
Radiation Dosage
Article
Linear particle accelerator
Cell Line
Polyethylene Glycols
030218 nuclear medicine & medical imaging
Mice
03 medical and health sciences
0302 clinical medicine
Hounsfield scale
Image Processing, Computer-Assisted
Animals
Humans
Computer Simulation
Image analysis
General Nursing
Phantoms, Imaging
Attenuation
Detector
Reproducibility of Results
Cone-Beam Computed Tomography
020601 biomedical engineering
Angular spectrum method
Gold
Particle Accelerators
Tomography, X-Ray Computed
Monte Carlo Method
Algorithms
Software
Biomedical engineering
Subjects
Details
- ISSN :
- 20571976
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Biomedical Physics & Engineering Express
- Accession number :
- edsair.doi.dedup.....41bf2d4712effa5265658dd0b3eece00