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The effects of gene polymorphisms on susceptibility to acute GVHD and survival of allogeneic HSCT recipients: IL-10 gene polymorphisms as a more accessible target to predict prognosis
- Source :
- Human immunology. 81(1)
- Publication Year :
- 2019
-
Abstract
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a therapeutic modality commonly used to treat hematological and immunological disorders. Among the main complications of allo-HSCT is the acute graft-versus-host disease (a-GVHD), a condition which accounts for a high incidence of mortality. Several genes encoding inflammatory mediators may present polymorphisms, which have been implicated in the risk of developing a-GVHD. In our study, we investigated the association between genotypes of cytokine-encoding genes and the incidence and severity of a-GVHD and survival of HSCT recipients. No statistically significant association was found between IL and 6-174 G/C, INF-γ + 874 T/A, TNF-α -238 A/G, -308 A/G and IL-10-819C/T, -592 A/C polymorphisms and the presence or severity of a-GVHD. A higher risk of a-GVHD was associated with the IL-10-1082 GG genotype compared to the AA + AG genotypes of recipients and donors. The IL-10-1082 genotype can be used as a prognostic determinant to predict which HSCT recipient will be more responsive to the transplant. Thus, cytokine gene assays may be useful in the individualization of prophylactic regimens and for an appropriate selection of immunosuppressants based on the HSCT recipient’s responsiveness.
- Subjects :
- 0301 basic medicine
Adult
Male
Adolescent
Genotype
medicine.medical_treatment
Immunology
Graft vs Host Disease
chemical and pharmacologic phenomena
Hematopoietic stem cell transplantation
Disease
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
immune system diseases
Predictive Value of Tests
Immunology and Allergy
Medicine
Humans
Genetic Predisposition to Disease
Child
Polymorphism, Genetic
business.industry
Incidence (epidemiology)
Hematopoietic Stem Cell Transplantation
Interleukin
General Medicine
medicine.disease
Allografts
Interleukin-10
Survival Rate
Interleukin 10
surgical procedures, operative
030104 developmental biology
Graft-versus-host disease
Hematologic Neoplasms
Acute Disease
Tumor necrosis factor alpha
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 18791166
- Volume :
- 81
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Human immunology
- Accession number :
- edsair.doi.dedup.....41b92eb6a33ff80ae61435e449aeb341