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Altered neurochemical metabolites in Alzheimer's disease patients with unawareness of deficits
- Source :
- International psychogeriatrics. 26(3)
- Publication Year :
- 2013
-
Abstract
- Background:Unawareness of deficits is common and is associated with poor outcomes in Alzheimer's disease (AD); however, little is known about correlated neurobiochemical changes.Methods:Proton magnetic resonance spectroscopy was used to examine neurobiochemical correlates of unawareness of deficits as assessed by the Dementia Deficit Scale in 36 patients with AD. Magnetic resonance spectroscopy spectra were acquired from the anterior cingulate area and right orbitofrontal area. Concentrations of N-acetyl-aspartate (NAA), total creatine, and other neurometabolites were calculated.Results:Nineteen (52.8%) participants had relative unawareness of deficits. This condition was negatively correlated with NAA/creatine in the anterior cingulate area (β = −0.36, p = 0.025) and positively correlated with NAA/creatine in the right orbitofrontal area (β = 0.41, p = 0.009) after controlling for dementia severity.Conclusions:These findings suggest unawareness of deficits in AD was associated with the altered neurochemical metabolites in the anterior cingulate area and right orbitofrontal area. However, the two areas might have opposite neuronal functions in unawareness of deficits.
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Disease
Neuropsychological Tests
Creatine
Gyrus Cinguli
chemistry.chemical_compound
Neurochemical
Alzheimer Disease
Reference Values
Internal medicine
medicine
Dementia
Humans
Dominance, Cerebral
Aged
Aged, 80 and over
Aspartic Acid
Total creatine
Awareness
medicine.disease
Prognosis
Proton magnetic resonance
Frontal Lobe
Psychiatry and Mental health
Clinical Psychology
Endocrinology
chemistry
Anterior cingulate area
Female
Geriatrics and Gerontology
Psychology
Gerontology
Neuroscience
Subjects
Details
- ISSN :
- 1741203X
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International psychogeriatrics
- Accession number :
- edsair.doi.dedup.....41b8fad588be791d84deb0d27dd64c00