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Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition
- Source :
- Journal of Endocrinology. 219:29-37
- Publication Year :
- 2013
- Publisher :
- Bioscientifica, 2013.
-
Abstract
- The inhibition of maternal prolactin production in late lactation leads to metabolic syndrome and hypothyroidism in adult offspring. Physical training is a therapeutic strategy that could prevent or reverse this condition. We evaluated the effects of a short-duration low-intensity running wheel training program on the metabolic and hormonal alterations in rats. Lactating Wistar rats were treated with bromocriptine (Bro, 1 mg twice a day) or saline on days 19, 20, and 21 of lactation, and the training of offspring began at 35 days of age. Offspring were divided into sedentary and trained controls (C-Sed and C-Ex) and sedentary and trained Bro-treated rats (Bro-Sed and Bro-Ex). Chronic exercise delayed the onset of weight gain in Bro-Ex offspring, and the food intake did not change during the experimental period. At 180 days, visceral fat mass was higher (+46%) in the Bro-Sed offspring than in C-Sed and Bro-Ex rats. As expected, running capacity was higher in trained animals. Most parameters observed in the Bro-Sed offspring were consistent with hypothyroidism and metabolic syndrome and were reversed in the Bro-Ex group. Chronic exercise did not influence the muscle glycogen in the C-Ex group; however, liver glycogen was higher (+30%) in C-Ex group and was unchanged in both Bro offspring groups. Bro-Ex animals had higher plasma lactate dehydrogenase levels, indicating skeletal muscle damage and intolerance of the training program. Low-intensity chronic training is able to normalize many clinical aspects in Bro animals; however, these animals might have had a lower threshold for exercise adaptation than the control rats.
- Subjects :
- Male
medicine.medical_specialty
Offspring
Endocrinology, Diabetes and Metabolism
Mothers
Weaning
Motor Activity
chemistry.chemical_compound
Endocrinology
Physical Conditioning, Animal
Internal medicine
Lactation
medicine
Animals
Obesity
Rats, Wistar
Bromocriptine
Metabolic Syndrome
L-Lactate Dehydrogenase
medicine.diagnostic_test
Glycogen
business.industry
Muscles
Lipid Metabolism
medicine.disease
Prolactin
Rats
medicine.anatomical_structure
chemistry
Female
medicine.symptom
Metabolic syndrome
Lipid profile
business
Weight gain
medicine.drug
Subjects
Details
- ISSN :
- 14796805 and 00220795
- Volume :
- 219
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....41b6a348637de46e6b828752d5787d53