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Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes
- Publication Year :
- 1990
-
Abstract
- To document the in vivo interactions occurring between the immune system and HIV replicating cells, we analyzed using in situ hybridization the production of IL-1 beta, IL-6, IL-2, and INF-gamma in eight hyperplastic lymph nodes from HIV-1 infected patients. Numerous IL-1 beta- and IL-6-producing cells associated in clusters were detected in sinuses. Few individual IL-1 beta- and IL-6-producing cells were present in interfollicular and follicular areas. IL-2- and INF-gamma-producing cells were observed in all lymph node compartments, with a selective enrichment in germinal centers. The amount and distribution of IL-1 beta, IL-6-, and IL-2-producing cells in HIV lymph nodes were not different from those found in six HIV unrelated hyperplastic lymph nodes. In contrast, a higher level of INF-gamma production was observed in HIV-1 lymph nodes. The CD8+ cells that accumulate in germinal centers of HIV lymph nodes (and not in non-HIV germinal centers) were actively involved in this INF-gamma production. INF-gamma synthesizing cells were in direct contact with cells containing HIV core antigens and HIV RNA. Thus a high INF-gamma production may characterize anti-HIV T cell immune response, potentially contributing to control of viral spreading as well as to the development of follicle lysis.
- Subjects :
- Adult
HIV Antigens
HIV Core Protein p24
Gene Products, gag
HIV Infections
Biology
Interferon-gamma
Immune system
Antigen
medicine
Lymph node stromal cell
Humans
Lymph node
Interleukin-6
Interleukins
Viral Core Proteins
Germinal center
Nucleic Acid Hybridization
General Medicine
Virology
medicine.anatomical_structure
Immunology
Interleukin-2
RNA, Viral
Lymph
Lymph Nodes
CD8
Research Article
Interleukin-1
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....41b640ed4d4ecb853d7e7a9c85582983