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Gastric antral vascular ectasia (GAVE) in a non-cirrhotic patients with diabetes: case report and possible pathophysiological mechanism
- Source :
- BMJ case reports. 2010
- Publication Year :
- 2012
-
Abstract
- Gastric antral vascular ectasia (GAVE) syndrome is an uncommon but well-described cause of recurrent upper gastrointestinal bleeding or iron deficiency anaemia. Atiology is unknown but several associated diseases have been reported like connective tissue or autoimmune disorders or cirrhosis. Cases have been reported in systemic sclerosis, achlorhydia, atrophic gastritis and chronic renal failure. The most common cause is portal hypertension and portal hypertensive gastropathy. This is especially so after eradication of oesophageal varices by sclerotherapy or banding. Diabetic complications are characterised by microvascular diseases especially in the retina, glomerulus and vasa nervorum. It involves apoptosis and remodelling of endothelial cells. Hyperglycaemia is an essential cause of reactive oxygen species (ROS)-mediated oxidative stress in this complication. Angiopathy of gastric mucosa in diabetes mellitus has not been reported so far in the literature. We are presenting an interesting case of diabetes mellitus with gastric vascular ectasia without evidence of any other systemic illness.
- Subjects :
- Adult
medicine.medical_specialty
Pathology
Cirrhosis
Atrophic gastritis
Iron
Portal hypertensive gastropathy
Light Coagulation
Gastroenterology
Article
Angiopathy
Diabetes Complications
Diagnosis, Differential
Internal medicine
Ectasia
medicine
Humans
business.industry
Gastric antral vascular ectasia
General Medicine
medicine.disease
Portal hypertension
Female
Upper gastrointestinal bleeding
business
Gastric Antral Vascular Ectasia
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 2010
- Database :
- OpenAIRE
- Journal :
- BMJ case reports
- Accession number :
- edsair.doi.dedup.....41ae881546b6482e5e6f144fa9f44b57