Supplementary Figures from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

PDF file 831K, Supplementary Figures. Supplementary Fig. 1. A schematic diagram of the methods, datasets and patient samples used in this study. Supplementary Fig. 2. Correlogram of the 10 poor outcome. signature genes. Supplementary Fig. 3. Validation of the 10-gene signature - Kaplan-Meyer plot. Supplementary Fig. 4. Real-time PCR of poor outcome signature genes in normal, primary, and metastatic ovarian cancer samples. Supplementary Fig. 5. Increase in COL11A1 expression in recurrent tumors in comparison to primary ovarian tumors. Supplementary Fig. 6. Confinement of COL11A1 expression to intra- and peri-tumoral stroma - immunohistochemical detection. Supplementary Fig. 7. Knockdown of COL11A1 in the A2780 ovarian cancer cell line - qPCR and Western blot