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Clinical profile of juvenile primary hyperparathyroidism: a prospective study
- Source :
- Endocrine. 59(2)
- Publication Year :
- 2017
-
Abstract
- Juvenile primary hyperparathyroidism is uncommon and more symptomatic than the adult counterpart. The aim of this prospective monocentric study, conducted in a tertiary referral center, was to evaluate the clinical, biochemical, and densitometric data, and the outcome of a series of patients with juvenile primary hyperparathyroidism. The study group included 154 patients with sporadic and familial juvenile primary hyperparathyroidism, aged ≤40 years. Relative frequency of sporadic and familial forms, comparison of the clinical and biochemical characteristics, rate of cure after parathyroidectomy and the outcome of patients not undergoing surgery were evaluated. Familial cases (n = 42) were younger, less frequently females, and had milder disease compared to sporadic cases (n = 112). No difference was observed in biochemical and densitometric parameters. Among patients undergoing parathyroidectomy (n = 116), familial cases had a higher rate of multigland disease and a higher persistence/relapse rate compared to sporadic cases (73 vs. 3.6% and 48.1 vs. 5.7%, respectively). Patients who did not undergo parathyroidectomy had stable clinical, biochemical, and densitometric parameters during follow-up (median 27 months). Using the cut-off age of 25 years, there was no difference in clinical, biochemical and densitometric parameters between younger and older patients, with the exception of parathyroid hormone and phosphate, which were significantly lower and higher, respectively, in patients
- Subjects :
- Male
Pathology
Familial hyperparathyroidism
FIHP
MEN1
Nephrolithiasis
Young hyperparathyroidism
Endocrinology, Diabetes and Metabolism
Endocrinology
medicine.medical_treatment
Parathyroid hormone
Disease
Gastroenterology
0302 clinical medicine
Absorptiometry, Photon
Bone Density
Femur
Prospective Studies
Prospective cohort study
Child
Lumbar Vertebrae
Age Factors
Hyperparathyroidism, Primary
Diabetes and Metabolism
Parathyroid Hormone
030220 oncology & carcinogenesis
Female
Parathyroidectomy
Adult
medicine.medical_specialty
Adolescent
Osteocalcin
030209 endocrinology & metabolism
03 medical and health sciences
Young Adult
Internal medicine
Diabetes mellitus
medicine
Juvenile
Humans
Serum Albumin
business.industry
medicine.disease
Calcium
business
Primary hyperparathyroidism
Biomarkers
Subjects
Details
- ISSN :
- 15590100
- Volume :
- 59
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....41959772d783d6b8a3996d7e91e93862