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A Hierarchical Cluster Analysis of Normal-Tension Glaucoma Using Spectral-Domain Optical Coherence Tomography Parameters

Authors :
Yong Woo Ji
Naeun Lee
Gong Je Seong
Kyung Rim Sung
Chan Yun Kim
Hye Sun Lee
Samin Hong
Hyoung Won Bae
Source :
Journal of Glaucoma. 24:328-333
Publication Year :
2015
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2015.

Abstract

Purpose Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses. Patients and methods A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous subgroups based on these variables using a hierarchical cluster analysis, and compared clusters to evaluate diverse NTG characteristics. Results Three clusters were found after hierarchical cluster analysis. Cluster 1 (62 eyes) had the thickest RNFL and widest rim area, and showed early glaucoma features. Cluster 2 (60 eyes) was characterized by the largest cup/disc ratio and cup volume, and showed advanced glaucomatous damage. Cluster 3 (78 eyes) had small disc areas in SD-OCT and were comprised of patients with significantly younger age, longer axial length, and greater myopia than the other 2 groups. Conclusions A hierarchical cluster analysis of SD-OCT scans divided NTG patients into 3 groups based upon ONH parameters and RNFL thicknesses. It is anticipated that the small disc area group comprised of younger and more myopic patients may show unique features unlike the other 2 groups.

Details

ISSN :
10570829
Volume :
24
Database :
OpenAIRE
Journal :
Journal of Glaucoma
Accession number :
edsair.doi.dedup.....4193c1bc5ed29e22ce328e8e231be3c1
Full Text :
https://doi.org/10.1097/ijg.0000000000000159