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A Hierarchical Cluster Analysis of Normal-Tension Glaucoma Using Spectral-Domain Optical Coherence Tomography Parameters
- Source :
- Journal of Glaucoma. 24:328-333
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Purpose Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses. Patients and methods A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous subgroups based on these variables using a hierarchical cluster analysis, and compared clusters to evaluate diverse NTG characteristics. Results Three clusters were found after hierarchical cluster analysis. Cluster 1 (62 eyes) had the thickest RNFL and widest rim area, and showed early glaucoma features. Cluster 2 (60 eyes) was characterized by the largest cup/disc ratio and cup volume, and showed advanced glaucomatous damage. Cluster 3 (78 eyes) had small disc areas in SD-OCT and were comprised of patients with significantly younger age, longer axial length, and greater myopia than the other 2 groups. Conclusions A hierarchical cluster analysis of SD-OCT scans divided NTG patients into 3 groups based upon ONH parameters and RNFL thicknesses. It is anticipated that the small disc area group comprised of younger and more myopic patients may show unique features unlike the other 2 groups.
- Subjects :
- Adult
Male
Retinal Ganglion Cells
medicine.medical_specialty
Intraocular pressure
genetic structures
Optic Disk
Nerve fiber layer
Glaucoma
chemistry.chemical_compound
Nerve Fibers
Optical coherence tomography
Ophthalmology
Normal tension glaucoma
Optic Nerve Diseases
medicine
Cluster Analysis
Humans
Low Tension Glaucoma
Intraocular Pressure
medicine.diagnostic_test
business.industry
Retinal
Middle Aged
medicine.disease
eye diseases
Hierarchical clustering
medicine.anatomical_structure
chemistry
Optic nerve
Optometry
Female
sense organs
business
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 10570829
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Glaucoma
- Accession number :
- edsair.doi.dedup.....4193c1bc5ed29e22ce328e8e231be3c1
- Full Text :
- https://doi.org/10.1097/ijg.0000000000000159