Back to Search
Start Over
Therapeutic Potential of Lung Epithelial Progenitor Cells Derived from Embryonic and Induced Pluripotent Stem Cells
- Source :
- Annual Review of Medicine. 62:95-105
- Publication Year :
- 2011
- Publisher :
- Annual Reviews, 2011.
-
Abstract
- Embryonic stem (ES) cells derived from preimplantation blastocysts and induced pluripotent stem (iPS) cells generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide a possible unlimited source of cells that could be differentiated into lung progenitor cells for potential clinical use in pulmonary regenerative medicine. Because of inherent difficulties in deriving endodermal cells from undifferentiated cell cultures, applications using lung epithelial cells derived from ES and iPS cells have lagged behind similar efforts devoted to other tissues, such as the heart and spinal cord. However, during the past several years, significant advances in culture, differentiation, and purification protocols, as well as in bioengineering methodologies, have fueled enthusiasm for the development of stem cell–based lung therapeutics. This article provides an overview of recent research achievements and discusses future technical challenges that must be met before the promise of stem cell applications for lung disease can be realized.
- Subjects :
- Lung Diseases
Pathology
medicine.medical_specialty
Somatic cell
Induced Pluripotent Stem Cells
Cell Culture Techniques
Biology
Regenerative Medicine
Regenerative medicine
Article
General Biochemistry, Genetics and Molecular Biology
Mice
medicine
Animals
Humans
Progenitor cell
Induced pluripotent stem cell
Lung
Cell potency
Embryonic Stem Cells
Tissue Engineering
Epithelial Cells
General Medicine
Embryonic stem cell
Rats
Cell biology
Endothelial stem cell
Stem cell
Subjects
Details
- ISSN :
- 1545326X and 00664219
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Annual Review of Medicine
- Accession number :
- edsair.doi.dedup.....41936173229ca2bb15d1113761e5d9ce