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Cationic Polythiophenes as Gene Delivery Enhancer
- Source :
- ACS applied materialsinterfaces. 9(20)
- Publication Year :
- 2017
-
Abstract
- There is urgent demand of easily available and highly effective method to improve transgene performance of polymeric gene carriers at low consumption of delivery materials. We developed biocompatible multicomponent nanocomposites in which small quantities of cationic polythiophenes were engineered into the outer shell of polypeptide/DNA polyplexes without covalent linkages. We revealed the introduction of polythiophenes in small quantities led to multiple outcomes including modulation of polyplex size and zeta potential, increase in polyplex stability, promotion of endolysosome membrane disruption, light-induced generation of reactive oxygen species (ROS), and significant enhancement of gene delivery to tumor cells. The factors such as structural architectures, molecular weights, photosensitizing capability, and percentage composition of polythiophenes were investigated.
- Subjects :
- Materials science
Endolysosome membrane
Polymers
Transgene
Cationic polymerization
Gene Transfer Techniques
Nanotechnology
02 engineering and technology
Thiophenes
Gene delivery
010402 general chemistry
021001 nanoscience & nanotechnology
Transfection
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
chemistry
Covalent bond
Cations
Biophysics
Zeta potential
Polythiophene
General Materials Science
0210 nano-technology
Enhancer
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 9
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....4191e8180dfe330c50bbb4cc15812ac6