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Polimorphonuclear Cell-Mediated Oxidative Stress: Sink for Reactive Oxygen Species and Cell Various Type Damage
- Source :
- Immunopharmacology and Immunotoxicology. 28:153-164
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- Reactive oxygen species (ROS) are produced in animals and humans under physiologic and pathologic conditions. Polymorphonuclear cells (PMNs) and other professional phagocytes are able to generate large amounts of ROS that have not only antimicrobial capacity but are also deleterious to mammalian cells and responsible for many chronic diseases. In particular, ROS produced in large amounts by the massively infiltrating leukocytes in inflammed tissues are believed to constitute a major tissue-destructive force and may contribute significantly to the pathogenesis of several inflammatory diseases. Inflammation can accelerate the development of cancer: in fact, it seems that a part of the predisposition to cancer may be attributed to the oxidants released by the phagocytes at inflammatory site and then to the effects of continuous damage over a life span by ROS. The focus of this study was to investigate the differential capacity of ROS capture and the relative cellular damage degree in gastric, intestinal and fibroblastic cell lines. These various cell types were in vitro used as sink for ROS released by co-cultured fMLP-stimulated human polymorphonuclear cells. Our data demonstrated that cell lines showed a differential capacity of ROS capture correlated to cellular damage, probably due to a different cell susceptibilty to the oxidative challenge produced by stimulated PMNs.
- Subjects :
- Adult
Cell Survival
Neutrophils
Immunology
Cell
Cell Count
CHO Cells
In Vitro Techniques
Biology
Toxicology
medicine.disease_cause
Pathogenesis
Cell Line, Tumor
Cricetinae
medicine
Animals
Humans
Immunology and Allergy
Pharmacology
chemistry.chemical_classification
Reactive oxygen species
Life span
Stomach
General Medicine
Fibroblasts
Cell mediated immunity
Cell biology
Intestines
N-Formylmethionine Leucyl-Phenylalanine
Oxidative Stress
medicine.anatomical_structure
Polymorphonuclear cells
chemistry
Reactive Oxygen Species
Oxidative stress
Subjects
Details
- ISSN :
- 15322513 and 08923973
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Immunopharmacology and Immunotoxicology
- Accession number :
- edsair.doi.dedup.....418b4b2dee658e237e13c7fcb063a597