Back to Search
Start Over
The Survival Benefit of Postoperative Bacterial Infections in Patients With Glioblastoma Multiforme: Myth or Reality?
- Source :
- Frontiers in Neurology, Frontiers in Neurology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Glioblastoma multiforme (GBM), the most common malignant brain tumor, universally carries a poor prognosis. Despite aggressive multimodality treatment, the median survival is ~18–20 months, depending on molecular subgroups. A long history of observations suggests antitumor effects of bacterial infections against malignant tumors. The present review summarizes and critically analyzes the clinical data providing evidence for or against the survival benefit of post-operative bacterial infections in GBM patients. Furthermore, we explore the probable underlying mechanism(s) from basic science studies on the topic. There are plausible explanations from immunobiology for the mechanism of the “favorable effect” of bacterial infections in GBM patients. However, available clinical literature does not provide a definitive association between postoperative bacterial infection and prolonged survival in GBM patients. The presently available, single-/multi-center and national database retrospective case-control studies on the topic provide conflicting results. A prospective randomized study on the subject is clearly not possible. Immunobiology literature supports development of genetically modified bacteria as part of multimodal regimen against GBM.
- Subjects :
- Oncology
medicine.medical_specialty
business.industry
Basic science
Mechanism (biology)
Mini Review
Brain tumor
medicine.disease
lcsh:RC346-429
immune response
glioblastoma multiforme
Regimen
Survival benefit
bacterial infections
Neurology
Internal medicine
survival benefit
Medicine
mechanism(s)
National database
In patient
Neurology (clinical)
business
lcsh:Neurology. Diseases of the nervous system
Glioblastoma
Subjects
Details
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....4189d35e11563cc044bcfff70d5d36c5