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Efficacy of bright light therapy in bipolar depression
- Source :
- Psychiatry research. 260
- Publication Year :
- 2017
-
Abstract
- For 30 years, bright light therapy (BLT) has been considered as an effective, well-tolerated treatment for seasonal affective disorder (SAD). Because of low response rates, new treatment strategies are needed for bipolar depression (BD), which resembles SAD in certain respects. Few placebo-controlled studies of BLT efficacy have been carried out for BD. Accordingly, this study evaluates the efficacy and safety of BLT as an add-on treatment for BD. Thirty-two BD outpatients were randomly assigned to BLT (10000lx) or dim light (DL,500lx). During a two-week period, light was administered each morning for 30min. The Hamilton Rating Scale for Depression and the Montgomery-Ǻsberg Depression Rating Scale assessed clinical outcome, and the UKU Side Effects Rating Scale evaluated side effects. No significant difference was observed in baseline depression scores in the two groups. Response rates for BLT and DL were 81% and 19%, and remission rates were 44% and 12.5%, respectively. Analyses showed statistically significant reductions in depression scores for the BLT group compared with the DL group on all scales. Side effects were similar in both groups, with headache as the most common side effect. The results suggest that BLT is an effective and safe add-on treatment for BD.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Bipolar Disorder
Adolescent
03 medical and health sciences
Young Adult
0302 clinical medicine
Double-Blind Method
Internal medicine
Medicine
Humans
Biological Psychiatry
Depression (differential diagnoses)
Aged
Psychiatric Status Rating Scales
Bright light therapy
business.industry
Seasonal Affective Disorder
Middle Aged
Phototherapy
030227 psychiatry
Psychiatry and Mental health
Treatment Outcome
Treatment strategy
Female
Seasons
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727123
- Volume :
- 260
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....4186a11a3e3b2551e578f12a6e2a9e54