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MRI guidance technology development in a large animal model for hyperlocal analgesics delivery to the epidural space and dorsal root ganglion
- Source :
- Journal of neuroscience methods. 312
- Publication Year :
- 2018
-
Abstract
- Background Development of new analgesic drugs or gene therapy vectors for spinal delivery will be facilitated by “hyperlocal” targeting of small therapeutic injectate volumes if spine imaging technology can be used that is ready for future clinical translation. New Method This study provides methods for MRI-guided drug delivery to the periganglionic epidural space and the dorsal root ganglion (DRG) in the Yucatan swine. Results Phantom studies showed artifact-corrected needle localization with frequency encoding parallel to the needle shaft, while maximizing bandwidth (125 KHz) minimized needle artifact. A custom constructed 8–12 element surface coil (phased array) wrapped over the spine in conjunction with lateral recumbent positioning achieved diagnostic quality signal to noise ratio at the depth of the DRG and afforded transforaminal access via anterolateral or posterolateral vectors, as well as interlaminar access. Swine epidural anatomy was homologous with human anatomy. Injectate containing 2% gadolinium allowed imaging of injectate volumes in increments as small as 10 microliters and discrimination of epidural flow from intraparenchymal injectate delivery into a DRG. All technical and technological elements of the procedure appear clinically translatable. Comparison with Existing Methods Computed tomographic or fluoroscopic guidance cannot directly visualize drug delivery into the DRG due to contrast medium toxicity, nor reliably identify epidural injection volumes of Conclusions MRI-guided hyperlocal delivery in swine provides a translatable and faithful model of future human spinal novel drug- or gene therapy vector delivery.
- Subjects :
- 0301 basic medicine
Epidural Space
Swine
Injections, Epidural
Frequency encoding
Technology development
Article
03 medical and health sciences
0302 clinical medicine
Drug Delivery Systems
Dorsal root ganglion
Ganglia, Spinal
Surface coil
medicine
Animals
Neuronavigation
Analgesics
business.industry
Phantoms, Imaging
General Neuroscience
Magnetic Resonance Imaging
Epidural space
Contrast medium
030104 developmental biology
medicine.anatomical_structure
Drug delivery
Swine, Miniature
business
Artifacts
030217 neurology & neurosurgery
Large animal
Biomedical engineering
Subjects
Details
- ISSN :
- 1872678X
- Volume :
- 312
- Database :
- OpenAIRE
- Journal :
- Journal of neuroscience methods
- Accession number :
- edsair.doi.dedup.....417adf1ea68d084a4e6abdedc664e398