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Dysfunctional RNA binding proteins and stress granules in multiple sclerosis
- Source :
- Journal of Neuroimmunology. 324:149-156
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Dysfunction of the RNA binding protein (RBP) heterogeneous nuclear ribonuclear protein A1 (hnRNP A1) has been shown to contribute to the pathogenesis of neurodegenerative diseases, but its involvement in multiple sclerosis (MS) is largely unknown. In a neuronal cell line, interferon-γ caused hnRNP A1 nucleocytoplasmic mislocalization; colocalization of hnRNP A1 in stress granules (SGs); and inhibition of translation. Neurons in the brain of a MS patient showed pathogenic RBP dysfunction, including nuclear depletion of hnRNP A1, its mislocalization to the cytoplasm, and its colocalization in SGs. These data indicate a role for dysfunctional hnRNP A1 in the pathogenesis of MS.
- Subjects :
- Male
0301 basic medicine
Multiple Sclerosis
Heterogeneous Nuclear Ribonucleoprotein A1
viruses
genetic processes
Immunology
RNA-binding protein
environment and public health
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Stress granule
Cell Line, Tumor
medicine
Humans
Immunology and Allergy
Chemistry
Neurodegeneration
RNA-Binding Proteins
Colocalization
Translation (biology)
Middle Aged
medicine.disease
Cell biology
Oxidative Stress
030104 developmental biology
Neurology
Cytoplasm
health occupations
Neurology (clinical)
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 324
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....4174dcf87f6823e7ca03cff97e831008