Targeting Cancer Metabolism Plasticity with JX06 Nanoparticles via Inhibiting PDK1 Combined with Metformin for Endometrial Cancer Patients with Diabetes

Authors :: Xiao Yang
Yuan Cheng
Jingyi Zhou
Lingpu Zhang
Xingchen Li
Zhiqi Wang
Shenyi Yin
LiRong Zhai
Ting Huang
Xiaotong Wu
Boqiang Shen
Yangyang Dong
Lijun Zhao
Yujing Chi
Yuanyuan Jia
Jiaqi Wang
Yijiao He
Xiying Dong
Haihua Xiao
Jianliu Wang
Source :: Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(8)
Publication Year :: 2021
Abstract: Diabetes is closely related to the occurrence of endometrial cancer (EC) and its poor prognosis. However, there is no effective clinical treatment for EC patients with diabetes (patient

Subjects :: General Chemical Engineering
Morpholines
General Engineering
General Physics and Astronomy
Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Metformin
Endometrial Neoplasms
Mice
Cell Line, Tumor
Disulfiram
Diabetes Mellitus
Animals
Humans
Nanoparticles
General Materials Science
Female
Cell Proliferation

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