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Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation
- Source :
- The Korean Journal of Internal Medicine
- Publication Year :
- 2015
- Publisher :
- Korean Association of Internal Medicine, 2015.
-
Abstract
- BACKGROUND/AIMS There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structural and functional remodeling. METHODS The study population consisted of 104 consecutive patients who underwent catheter ablation (CA) for AF (paroxysmal atrial fibrillation [PAF], 82; persistent atrial fibrillation [PeAF], 22). IAS thickness and left atrium volume (LAV) using TTE, and LA voltage (LA(VOL)) using 3-dimensional electroanatomical mapping system were assessed during sinus rhythm. RESULTS IAS thickness was significantly correlated with maximal LAV (LAV(max)) (r = 0.288, p = 0.003), mean LA(VOL) (r = -0.537, p < 0.001), total left atrium emptying fraction (LAEF(total); r = -0.213, p = 0.030), and active LAEF (LAEF(active); r = -0.249, p = 0.014). IAS thickness was greater in the high-risk group (≥ 2) compared to other groups according to CHA2DS2-VASc score (p = 0.019). During a follow-up of 19.6 months, 23 subjects (22.1%; PAF, 17; PeAF, 6) had recurrence of arrhythmia. Univariate analysis showed that LAV(max), minimal LAV, mean LA(VOL), LVEF(total), LVEF(active), and IAS thickness were associated with recurrence of arrhythmia. However, on multivariate analysis, only mean LA(VOL) and LAEF(active) were independent risk factors for recurrence. CONCLUSIONS Although IAS thickness showed significant correlations with parameters for LA structural and functional remodeling, this parameter alone could not independently predict recurrence of arrhythmia after CA for AF.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Paroxysmal atrial fibrillation
medicine.medical_treatment
Cardiology
Left atrium
Action Potentials
Catheter ablation
Predictive Value of Tests
Recurrence
Risk Factors
Internal medicine
Atrial Fibrillation
Multidetector Computed Tomography
medicine
Humans
In patient
Sinus rhythm
Prospective Studies
Aged
Univariate analysis
Chi-Square Distribution
Ejection fraction
Atrial Septum
business.industry
Heart atria
Atrial fibrillation
Atrial Remodeling
Middle Aged
medicine.disease
Echocardiography, Doppler
Treatment Outcome
medicine.anatomical_structure
ROC Curve
Area Under Curve
Multivariate Analysis
Catheter Ablation
Linear Models
Original Article
Atrial Function, Left
Female
Electrophysiologic Techniques, Cardiac
business
Subjects
Details
- ISSN :
- 20056648 and 12263303
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....4166d9203105ac271db1681df37e7fbc