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Plasma beta-globin DNA as a prognostic marker in chest pain patients
- Source :
- Clinica chimica acta; international journal of clinical chemistry. 368(1-2)
- Publication Year :
- 2005
-
Abstract
- Acute coronary syndrome may involve cell death and the release of nucleic acids into the circulation. We thus investigated whether plasma DNA concentrations are increased and determined its prognostic significance in patients with ACS.Real-time polymerase chain reaction was used to quantitatively measure the beta-globin gene from blood samples taken from patients presenting to an emergency department with chest pain of probable cardiac cause.Samples from 58 patients with chest pain, and from 21 age- and sex-matched healthy control subjects were analysed. Compared with the control group, median plasma DNA concentrations were increased 1.5-fold in patients with minor cardiac injury, were increased further in patients with STEA and STEMI, and were the highest in those patients who died within 2 years (P=0.0005; post-hoc Dunn's, P0.05). Median plasma DNA concentrations were higher in patients who later developed heart failure (1060 vs. 500 kGE/l; P=0.0095); higher in patients who later reinfarcted (1000 vs. 530 kGE/l; P=0.0298); higher in patients who had a cardiac arrest in that admission (1350 vs. 525 kGE/l; P=0.04); and were higher in patients who were readmitted within 6 months of discharge (725 vs. 475 kGE/l; P=0.04).Plasma DNA is a potential marker for post-ACS complications.
- Subjects :
- Adult
Male
medicine.medical_specialty
Acute coronary syndrome
Pathology
Programmed cell death
Chest Pain
Clinical Biochemistry
Chest pain
Biochemistry
Gastroenterology
law.invention
chemistry.chemical_compound
law
Internal medicine
medicine
Humans
Globin
Polymerase chain reaction
Aged
business.industry
Plasma dna
Biochemistry (medical)
General Medicine
Emergency department
DNA
Middle Aged
medicine.disease
Prognosis
Globins
chemistry
ROC Curve
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 368
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Accession number :
- edsair.doi.dedup.....41633a617495cb1657785c9a395273b8