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RNA-binding protein Csx1 is phosphorylated by LAMMER kinase, Lkh1, in response to oxidative stress in Schizosaccharomyces pombe
- Source :
- FEBS Letters. (18):3473-3478
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
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Abstract
- Recent studies have shown that global gene expression during oxidative stress in Schizosaccharomyces pombe is regulated by stress-induced activation and binding of Csx1 to atf1+ mRNA. However, the kinase responsible for the activation of Csx1 has not been identified. Here, we describe, for the first time, that Csx1 is phosphorylated by S. pombe LAMMER kinase, Lkh1, under oxidative conditions and that the stress-activated binding of the Csx1 to the atf1+ mRNA was also affected by Lkh1 and Spc1. These data indicate that concerted actions of Spc1 and Lkh1 are required for the activation of Csx1 during oxidative condition in the fission yeast S. pombe.
- Subjects :
- Biophysics
Lkh1
RNA-binding protein
Biochemistry
LAMMER kinase
Structural Biology
Schizosaccharomyces
Gene expression
Genetics
RNA, Messenger
Phosphorylation
Molecular Biology
Csx1
Messenger RNA
ATF1
biology
Kinase
RNA-Binding Proteins
Blood Proteins
Cell Biology
biology.organism_classification
Activating Transcription Factors
Oxidative stress
Schizosaccharomyces pombe
Mutation
Schizosaccharomyces pombe Proteins
Cyclin-dependent kinase 7
Protein Kinases
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....414b0d4841fbe12f8524070cca717d99
- Full Text :
- https://doi.org/10.1016/j.febslet.2007.06.053