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Development of hepatic pathology in GBV‐B‐infected red‐bellied tamarins ( Saguinus labiatus )
- Source :
- Journal of Medical Virology. 92:3584-3595
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- GB virus B (GBV‐B) is a New World monkey‐associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of anti‐viral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterised changes in tamarins. As early as two weeks post infection histological changes were noticeable, and these were established in all animals by six weeks. Despite high levels of liver‐associated viral RNA there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV‐B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.
- Subjects :
- replication
LIVER-DAMAGE
hepatitis virus
spread
IMMUNITY
Virus
03 medical and health sciences
0302 clinical medicine
Immune system
local infection
1108 Medical Microbiology
Fibrosis
Virology
medicine
Viral rna
C VIRUS
030212 general & internal medicine
animal models of infection
AGENT
Science & Technology
biology
PERSISTENCE
COMMON MARMOSETS
Saguinus labiatus
medicine.disease
biology.organism_classification
MODEL
Flavivirus
Infectious Diseases
T-CELLS
030211 gastroenterology & hepatology
Acute hepatitis C
Life Sciences & Biomedicine
Liver pathology
0605 Microbiology
Subjects
Details
- ISSN :
- 10969071 and 01466615
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology
- Accession number :
- edsair.doi.dedup.....4144ce9cb1d494d97e24d26115ba5d95