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High resolution copy number analysis of IRF4 translocation‐positive diffuse large B‐cell and follicular lymphomas
- Source :
- Genes, Chromosomes and Cancer. 52:150-155
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas.
- Subjects :
- Adult
Male
Cancer Research
Adolescent
DNA Copy Number Variations
DNA Mutational Analysis
Copy number analysis
Chromosomal translocation
Biology
Molecular Inversion Probe
Translocation, Genetic
Loss of heterozygosity
Young Adult
03 medical and health sciences
0302 clinical medicine
Genetics
medicine
Humans
Point Mutation
Child
Lymphoma, Follicular
In Situ Hybridization, Fluorescence
Aged
030304 developmental biology
Aged, 80 and over
Chromosome Aberrations
Comparative Genomic Hybridization
0303 health sciences
Base Sequence
Germinal center
Chromosome
Middle Aged
Germinal Center
medicine.disease
Molecular biology
Lymphoma
Xq28
Child, Preschool
030220 oncology & carcinogenesis
Interferon Regulatory Factors
Female
Lymphoma, Large B-Cell, Diffuse
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 10982264 and 10452257
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi.dedup.....4141cb76590e262fa2a0296f6b0f4b4e