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Effect of Supplementation with n-3 Fatty Acids Extracted from Microalgae on Inflammation Biomarkers from Two Different Strains of Mice
- Source :
- Journal of Lipids, Vol 2018 (2018)
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Background. Diabetes mellitus is considered a chronic noncommunicable disease in which inflammation plays a main role in the progression of the disease and it is known that n-3 fatty acids have anti-inflammatory properties. One of the most recent approaches is the study of the fatty acids of microalgae as a substitute for fish oil and a source rich in fatty acids EPA and DHA. Objective. To analyze the effect of supplementation with n-3 fatty acids extracted from microalgae on the inflammatory markers from two different strains of mice. Methods. Mice of two strains, db/db and CD1, were supplemented with n-3 fatty acids extracted from microalgae in lyophilized form and added to food; the experiment was carried out from week 8 to 16 of life. Flow cytometry was performed to determine the percentage of TCD4+ cells producing Th1 and Th2 cytokines. Results. Supplementation with microalgae fatty acids decreased the percentage of TCD4+ cells producing IFN-γ and TNF-α and increased the ones producing IL-17A and IL-12 in both strains; on the other hand, supplementation decreased percentage of TCD4+ cells producing IL-4 and increased the ones producing TGF-β. Conclusions. Microalgae n-3 fatty acids could be a useful tool in the treatment of diabetes as well as in the prevention of the appearance of health complications caused by inflammatory states.
- Subjects :
- 0301 basic medicine
Inflammation biomarkers
Article Subject
medicine.diagnostic_test
lcsh:QP1-981
CD1
Inflammation
Disease
030204 cardiovascular system & hematology
Biology
Fish oil
medicine.disease
Biochemistry
lcsh:Physiology
Flow cytometry
lcsh:Biochemistry
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Diabetes mellitus
medicine
N-3 fatty acids
lcsh:QD415-436
Food science
medicine.symptom
Subjects
Details
- Language :
- English
- ISSN :
- 20903049 and 20903030
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Journal of Lipids
- Accession number :
- edsair.doi.dedup.....4135a894b076f4f6a86bb64faaa14b5c