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Paper spray mass spectrometry utilizing TeslinĀ® substrate for rapid detection of lipid metabolite changes during COVID-19 infection
- Source :
- The Analyst
- Publication Year :
- 2020
-
Abstract
- The SARS-CoV-2 virus is known as the causal agent for the current COVID-19 global pandemic. The majority of COVID-19 patients develop acute respiratory distress syndrome (ARDS), while some experience a cytokine storm effect, which is considered as one of the leading causes of patient mortality. Lipids are known to be involved in the various stages of the lifecycle of a virus functioning as receptors or co-receptors that controls viral propagation inside the host cell. Therefore, lipid-related metabolomics aims to provide insight into the immune response of the novel coronavirus. Our study has focused on determination of the potential metabolomic biomarkers utilizing a Teslin® Substrate in paper spray mass spectrometry (PS-MS) for the development of a rapid detection test within 60 seconds of analysis time. In this study, results were correlated with PCR tests to reflect that the systemic responses of the cells were affected by the COVID-19 virus.
- Subjects :
- Paper
ARDS
Metabolite
Pneumonia, Viral
Biology
medicine.disease_cause
01 natural sciences
Biochemistry
Virus
Mass Spectrometry
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
Betacoronavirus
Metabolomics
Immune system
Nasopharynx
Electrochemistry
medicine
Environmental Chemistry
Humans
Receptor
Pandemics
Spectroscopy
030304 developmental biology
Coronavirus
0303 health sciences
SARS-CoV-2
010401 analytical chemistry
COVID-19
Discriminant Analysis
medicine.disease
Lipid Metabolism
Lipids
0104 chemical sciences
chemistry
Immunology
Cytokine storm
Coronavirus Infections
Biomarkers
Subjects
Details
- ISSN :
- 13645528
- Volume :
- 145
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- The Analyst
- Accession number :
- edsair.doi.dedup.....412b229fac274d2d29e0ca32ca6573fb