Back to Search
Start Over
Estimating liver function in a large cirrhotic cohort: Signal intensity of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI
- Publication Year :
- 2019
- Publisher :
- Elsevier B.V., 2019.
-
Abstract
- Background: To assess whether gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI study is useful to estimate liver function in comparison to the presence or absence of cirrhosis, Child Pugh (CP), Model for End-stage Liver Disease (MELD), ALBI scores and biochemical test. Methods: We retrospectively reviewed all consecutive Gd-EOB-DTPA-enhanced-MRI studies performed between 2010 and 2016 in patients with focal liver lesions undergoing clinical evaluation. Patients were divided in study and control group according to the presence of cirrhosis, and then classified by CP, MELD and ALBI. Signal intensity was calculated through the liver-to-muscle ratio in portal- (SI-POR) and hepatobiliary-phase(SI-HEP). Results: Three-hundred-three Gd-EOB-DTPA liver-enhanced-MRI studies were included. One-hundred-ninety-one patients (63%) were cirrhotic. SI-HEP was significantly lower in cirrhotic group (0.55 ± 0.29 vs 0.66 ± 0.40, p = 0.004).The SI-HEP progressively decreased from CP-A to CP-C (0.59 ± 0.28 to 0.25 ± 0.19, p < 0.0001) and a significant difference was found between MELD ≤ 9 and MELD > 9 groups (0.61 ± 0.31 vs 0.49 ± 0.28, p = 0.007). No differences between ALBI grades were evident. Among biochemical parameters a moderate correlation was found among SI-HEP and total bilirubin, AST and albumin. Conclusion: SI-HEP after Gd-EOB-DTPA-enhanced-MRI effectively stratified patients with different Child Pugh grades and MELD scores. This technique could hence be useful as a novel radiological marker to estimate the underlying liver function.
- Subjects :
- Gadolinium DTPA
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Bilirubin
Contrast Media
Gastroenterology
Liver cirrhosi
03 medical and health sciences
chemistry.chemical_compound
Liver disease
0302 clinical medicine
Magnetic resonance imaging
Liver Function Tests
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Hepatology
medicine.diagnostic_test
business.industry
Albumin
Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI
Middle Aged
medicine.disease
Image Enhancement
chemistry
Italy
Liver
030220 oncology & carcinogenesis
Liver function test
Cohort
030211 gastroenterology & hepatology
Female
Liver function
business
Liver function tests
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4122c42cdf0c8337906c59b8f7fd795a