Protection by GABA agonists, gamma-hydroxybutyric acid, and valproic acid against seizures evoked in epileptic chicks by hyperthermia

With microwave diathermy, febrile seizures were produced in epileptic chicks aged 2-5 days. Drugs that enhance GABAergic activity (i.e., GABA, muscimol, and progabide), as well as valproic acid and gamma-hydroxybutyric acid, produced dose-dependent increases in latency to onset of seizures.