Back to Search
Start Over
Review article: preventing hepatitis B graft infection in hepatitis B patients after liver transplantation: immunoglobulin vs anti-virals
Review article: preventing hepatitis B graft infection in hepatitis B patients after liver transplantation: immunoglobulin vs anti-virals
- Source :
- Alimentary Pharmacology & Therapeutics.
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background A critical aspect of liver transplantation in hepatitis B patients is to prevent graft reinfection with hepatitis B virus. The use of hepatitis B immune globulin after transplant was a significant milestone, which allowed prolonged graft and patient survival by controlling hepatitis B reinfection in liver grafts. The development of anti-viral treatments with oral nucleos(t)ide analogues, led to a further reduction in graft reinfection and improvement in patient survival. The combination of the aforementioned two therapies has been widely used in hepatitis B-associated liver transplants. Aims To address the post-transplant management of hepatitis B and provide updates on preventing graft reinfection. Methods We performed a literature search on Ovid and PubMed for randomised controlled trials or cohort studies in English, which investigated the effectiveness of hepatitis B immune globulin and anti-viral therapy on hepatitis B-associated transplants (1/2000-1/2020). Studies that met pre-established criteria were reviewed. Results Based on currently available evidence, an algorithm for post-transplant management with anti-viral therapy is proposed. Also, the management of recipients who received grafts from hepatitis B core antibody-positive donors is discussed. Conclusions The development of hepatitis B immune globulin and anti-viral treatments led to substantial improvement in graft and patient survival. The prevention of hepatitis B graft reinfection is complex and involves a broad interdisciplinary team.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Immunoglobulins
Liver transplantation
medicine.disease_cause
Antiviral Agents
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Randomized Controlled Trials as Topic
Hepatitis
Hepatitis B virus
Hepatitis B immune globulin
Hepatology
biology
business.industry
Hepatitis B
medicine.disease
Tissue Donors
Liver Transplantation
Review article
surgical procedures, operative
biology.protein
030211 gastroenterology & hepatology
Antibody
business
Cohort study
medicine.drug
Subjects
Details
- ISSN :
- 02692813
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....41179ba0355690703b66005957f6b942
- Full Text :
- https://doi.org/10.1111/apt.15999