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A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese
- Source :
- Journal of Alzheimer's disease : JAD. 58(1)
- Publication Year :
- 2017
-
Abstract
- Background Uric acid (UA) is a powerful antioxidant that may have neuroprotective properties, yet it is also a risk factor of vascular disease that predisposes individuals to cognitive impairment. Results from longitudinal studies on UA and cognitive decline remain controversial. Objective We examined the associations of baseline plasma UA level with follow-up cognitive function as well as cognitive decline over time among a large sample of middle-aged and older Chinese. Methods Data from China Health and Retirement Longitudinal Study (CHARLS) were used. Cognitive function, including episodic memory, mental intactness, and global cognition, were tested twice with 2-year interval. Plasma UA was measured at baseline. Basic demographics, life habits, and health status were considered as potential confounders. Multiple linear regression models and mixed-effects regression models were fitted. Results A total of 12,798 individuals aged above 45 years were eligible with the follow-up time ranging from 1.33 to 2.42 years. Both global cognitive function and mental intactness declined, while episodic memory remained stable over time. In multiple linear regression models, compared with the lowest baseline UA level, 3rd baseline UA quartile was associated with better follow-up global cognitive function (b = 0.425, p = 0.041) and episodic memory (b = 0.413, p = 0.004), and highest baseline UA quartile was associated with better follow-up mental intactness (b = 0.253, p = 0.041) in males; highest baseline UA level was associated with better follow-up cognition for each measure (b = 0.281∼0.768, p≤0.046) in females. Mixed-effects regression models suggested no significant baseline UA-by-time interactions on any cognitive measure. Conclusion Higher baseline UA level was associated with better cognition in later life but not with rates of cognitive decline among middle-aged and older Chinese.
- Subjects :
- Male
Longitudinal study
Neuropsychological Tests
03 medical and health sciences
0302 clinical medicine
Cognition
Asian People
Medicine
Humans
030212 general & internal medicine
Longitudinal Studies
Cognitive decline
Risk factor
Prospective cohort study
Episodic memory
Aged
Retrospective Studies
Aged, 80 and over
business.industry
General Neuroscience
Confounding
General Medicine
Middle Aged
Uric Acid
Psychiatry and Mental health
Clinical Psychology
Quartile
Linear Models
Female
Geriatrics and Gerontology
business
Cognition Disorders
030217 neurology & neurosurgery
Demography
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 58
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....4112d92dd418dc4100f99597e107ad87