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Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer
- Source :
- Carcinogenesis. 14:1085-1089
- Publication Year :
- 1993
- Publisher :
- Oxford University Press (OUP), 1993.
-
Abstract
- The p53 tumor suppressor gene is mutated in diverse types of human cancer, and the normal allele encodes a nuclear protein that regulates expression of cell cycle-related genes as a transcription factor. The wild-type of p53 protein exists as at least two forms of variants among human populations, ascribed to amino acid replacement at codon 72 of Arg by Pro. In this study, we show that this germ line Arg-Pro polymorphism at codon 72 of the p53 gene is associated with genetically determined susceptibility to smoking-induced lung cancer; a susceptible genotype Pro/Pro has a 1.7-fold higher risk of this cancer compared with other genotypes. This p53 polymorphism modulates risk to smoking-induced lung cancer independently of other genetic risk factors such as germ line polymorphism of CYP1A1 or GST1 genes.
- Subjects :
- Male
Risk
Cancer Research
Lung Neoplasms
Molecular Sequence Data
Adenocarcinoma
Biology
medicine.disease_cause
Polymerase Chain Reaction
Cytochrome P-450 Enzyme System
Polymorphism (computer science)
Carcinoma, Non-Small-Cell Lung
Genotype
medicine
Humans
Genetic Predisposition to Disease
Carcinoma, Small Cell
Allele
Codon
Lung cancer
Gene
Genetics
Mutation
Polymorphism, Genetic
Base Sequence
Smoking
Cancer
General Medicine
Genes, p53
medicine.disease
Phenotype
Carcinoma, Squamous Cell
Cancer research
Female
Subjects
Details
- ISSN :
- 14602180 and 01433334
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Carcinogenesis
- Accession number :
- edsair.doi.dedup.....411070e385265988a202f096eca41415