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Acyl sulfonamide anti-proliferatives. Part 2: activity of heterocyclic sulfonamide derivatives
- Source :
- Bioorganicmedicinal chemistry letters. 15(3)
- Publication Year :
- 2004
-
Abstract
- The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.
- Subjects :
- Vascular Endothelial Growth Factor A
Umbilical Veins
medicine.drug_class
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Biochemistry
Heterocyclic Compounds, 2-Ring
Inhibitory Concentration 50
Structure-Activity Relationship
Cell Line, Tumor
Drug Discovery
medicine
Structure–activity relationship
Humans
Molecular Biology
Cells, Cultured
Cell Proliferation
chemistry.chemical_classification
Sulfonamides
Organic Chemistry
Biological activity
In vitro
Sulfonamide
Endothelial stem cell
Vascular endothelial growth factor A
chemistry
Cell culture
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....410e29210dca2adecfd4f8bc1e0795cf