Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

Authors :: Kristin L. Andrews
J. Russell Lipford
Christine Sastri
Victor J. Cee
Jeff Winston
Andrew Tasker
Liping H. Pettus
Ryan Wurz
Christopher Mohr
Matthew R. Lee
Brian A. Lanman
Bin Wu
Nadia Guerrero
Thomas Nixey
Anthony B. Reed
Hui-Ling Wang
Source :: Bioorganic & Medicinal Chemistry Letters. 25:775-780
Publication Year :: 2015
Publisher :: Elsevier BV, 2015.
Abstract: PIM kinases are a family of Ser/Thr kinases that are implicated in tumorigenesis. The discovery of a new class of PIM inhibitors, 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines, is discussed with optimized compounds showing excellent potency against all three PIM isoforms.

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