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Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation
- Source :
- The American Journal of Dermatopathology. 39:696-699
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Allogeneic hematopoietic stem-cell transplantation and solid-organ transplantation are associated with an increased risk of secondary neoplasms. Indeterminate cell histiocytosis (ICH) is a rare disease composed of so-called indeterminate cells, an alleged cutaneous dendritic cell subset displaying histological and some ultrastructural and immunophenotypic features of Langerhans cells but lacking Birbeck granules. We report a case of cutaneous ICH occurring after allogeneic hematopoietic stem-cell transplantation for a myelodysplastic syndrome in a 56-year-old man. Microsatellite analysis demonstrated that the neoplastic cells were derived from the donor's hematopoietic system. This case broadens the spectrum of complications after stem-cell transplantation and demonstrates that cutaneous ICH in the setting of myelodysplastic syndromes may have a nonrelated origin to dysplastic myeloid cells.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Birbeck granules
medicine.medical_treatment
Dermatology
Hematopoietic stem cell transplantation
Skin Diseases
Pathology and Forensic Medicine
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Indeterminate Cell Histiocytosis
business.industry
Myelodysplastic syndromes
Hematopoietic Stem Cell Transplantation
General Medicine
Dendritic cell
Middle Aged
medicine.disease
Transplantation
Histiocytosis
Haematopoiesis
Myelodysplastic Syndromes
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- The American Journal of Dermatopathology
- Accession number :
- edsair.doi.dedup.....40fe5adee7891502f47086085968a009