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Silicosis and lung cancer risk in underground uranium miners
- Source :
- Health physics. 66(4)
- Publication Year :
- 1994
-
Abstract
- The presence of radiographic silicosis as a risk factor for lung cancer was assessed in a case-control study conducted within a study cohort of New Mexico underground uranium miners. Chest radiographs were interpreted for the presence of silicosis for 65 lung cancer cases and 216 controls. The presence of silicosis on the chest radiograph taken closest to the start of employment or on the latest radiograph available was not associated with lung cancer risk after adjustment for cumulative exposure to radon progeny. The odds ratio associated with the presence of any type of opacity indicative of pneumoconiosis on the chest x ray closest to the start of employment was 1.33 (95% confidence interval, 0.31-5.72). For the most recent available chest x ray, the corresponding odds ratio was 1.16 (95% confidence interval, 0.35-3.84). Although the findings are limited by the relatively small number of subjects, the lack of association of silicosis with lung cancer suggests that silica exposure should not be regarded as a major uncertainty in extrapolating radon risk estimates from miners to the general population.
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
Radon Daughters
Epidemiology
Health, Toxicology and Mutagenesis
Population
Silicosis
Occupational disease
Mining
Risk Factors
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Risk factor
Lung cancer
education
education.field_of_study
medicine.diagnostic_test
business.industry
Pneumoconiosis
Odds ratio
respiratory system
medicine.disease
respiratory tract diseases
Radon
Case-Control Studies
Uranium
Radiology
business
Chest radiograph
Nuclear medicine
Subjects
Details
- ISSN :
- 00179078
- Volume :
- 66
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Health physics
- Accession number :
- edsair.doi.dedup.....40ea617000df9eb9ea3df9569ce64682