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The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment
- Source :
- Journal of Clinical Endocrinology and Metabolism, 105(1), 290-304. Endocrine Society, Journal of Clinical Endocrinology and Metabolism, 105, 290-304, The Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Endocrinology and Metabolism, 105, 1, pp. 290-304
- Publication Year :
- 2020
-
Abstract
- Background Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality. This prospective study with 3 predetermined timepoints and a standardized treatment protocol investigates changes in sleep parameters during the first 2.5 years of acromegaly treatment. Methods Before initiation of acromegaly treatment (medical pretreatment followed by surgery), polysomnography (PSG) was performed in 27 consecutive patients with treatment-naive acromegaly. PSG was repeated after 1 year (N = 24) and 2.5 years (N = 23), and anthropometric and biochemical parameters were obtained. Results At baseline, 74.1% of the patients was diagnosed with OSAS. The respiratory disturbance index (RDI; P = 0.001), oxygen desaturation index (ODI; P = 0.001), lowest oxygen saturation (LSaO2; P = 0.007) and the Epworth Sleepiness Scale (ESS; P < 0.001) improved significantly during treatment, with the greatest improvement in the first year. After 2.5 years of treatment, all patients had controlled acromegaly. Of the 16 patients with repeated PSG and OSAS at baseline, 11 (68.8%) were cured of OSAS. Changes in RDI, ODI, LSaO2, and ESS correlated with insulin-like growth factor 1 levels. Conclusion OSAS has a high prevalence in active acromegaly. There is a substantial decrease in prevalence and severity of OSAS following acromegaly treatment, with the largest improvement during the first year. Most patients recover from OSAS following surgical or biochemical control of the acromegaly. Therefore, a PSG is advised after diagnosis of acromegaly. When OSAS is present, it should be treated and PSG should be repeated during acromegaly treatment.
- Subjects :
- Male
Sleepiness
Endocrinology, Diabetes and Metabolism
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Clinical Biochemistry
Polysomnography
Biochemistry
Neurosurgical Procedures
ODI
0302 clinical medicine
Endocrinology
Quality of life
Prevalence
sleep apnea syndrome
Prospective cohort study
Sleep Apnea, Obstructive
medicine.diagnostic_test
Human Growth Hormone
Epworth Sleepiness Scale
Middle Aged
Prognosis
Treatment Outcome
Dopamine Agonists
Disease Progression
IGF-1
Female
AcademicSubjects/MED00250
Adenoma
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
RDI
Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Internal medicine
Acromegaly
Respiratory disturbance index
medicine
Humans
Clinical Research Articles
Aged
business.industry
Biochemistry (medical)
Anthropometry
medicine.disease
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
Case-Control Studies
Growth Hormone-Secreting Pituitary Adenoma
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 0021972X
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Endocrinology and Metabolism, 105(1), 290-304. Endocrine Society, Journal of Clinical Endocrinology and Metabolism, 105, 290-304, The Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Endocrinology and Metabolism, 105, 1, pp. 290-304
- Accession number :
- edsair.doi.dedup.....40e1d3d63b3203474b8e0f03ffd18b81