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Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells
- Source :
- Radiation and Environmental Biophysics. 55:381-391
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Regarding the long-term goal to develop and establish laser-based particle accelerators for a future radiotherapeutic treatment of cancer, the radiobiological consequences of the characteristic short intense particle pulses with ultra-high peak dose rate, but low repetition rate of laser-driven beams have to be investigated. This work presents in vitro experiments performed at the radiation source ELBE (Electron Linac for beams with high Brilliance and low Emittance). This accelerator delivered 20-MeV electron pulses with ultra-high pulse dose rate of 10(10) Gy/min either at the low pulse frequency analogue to previous cell experiments with laser-driven electrons or at high frequency for minimizing the prolonged dose delivery and to perform comparison irradiation with a quasi-continuous electron beam analogue to a clinically used linear accelerator. The influence of the different electron beam pulse structures on the radiobiological response of the normal tissue cell line 184A1 and two primary fibroblasts was investigated regarding clonogenic survival and the number of DNA double-strand breaks that remain 24 h after irradiation. Thereby, no considerable differences in radiation response were revealed both for biological endpoints and for all probed cell cultures. These results provide evidence that the radiobiological effectiveness of the pulsed electron beams is not affected by the ultra-high pulse dose rates alone.
- Subjects :
- Materials science
Biophysics
Electrons
Electron
Radiation
Radiation Dosage
Linear particle accelerator
Cell Line
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
law
Relative biological effectiveness
Humans
DNA Breaks, Double-Stranded
Irradiation
General Environmental Science
Pulse (signal processing)
Lasers
Particle accelerator
Fibroblasts
Laser
030220 oncology & carcinogenesis
Particle Accelerators
Relative Biological Effectiveness
Biomedical engineering
Subjects
Details
- ISSN :
- 14322099 and 0301634X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Radiation and Environmental Biophysics
- Accession number :
- edsair.doi.dedup.....40db7a032d46289771ae54e735e90bf4