Back to Search
Start Over
Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight
- Source :
- Epigenetics. 10(10)
- Publication Year :
- 2015
-
Abstract
- Prenatal smoke exposure, maternal obesity, aberrant fetal growth, and preterm birth are all risk factors for offspring metabolic syndrome. Cord blood aryl-hydrocarbon receptor repressor (AHRR) DNA methylation is responsive to maternal smoking during pregnancy. AHRR serves not only to inhibit aryl-hydrocarbon receptor (AHR) transcription, which is involved in mediating xenobiotic metabolism, but it is also involved in cell growth and differentiation. Other than maternal smoking, other predictors of offspring AHRR DNA methylation status remain unknown; we sought to identify them among newborns. We enrolled pregnant women in the PROGRESS birth cohort in Mexico City. Using pyrosequencing, we analyzed DNA methylation of 3 CpG sites within the AHRR gene promoter from the umbilical cord blood of 531 infants. We used generalized estimating equations to account for the correlation of DNA methylation between CpG sites. Multivariable models were used to adjust for maternal age, BMI, education, parity, smoke-exposure, infant sex, gestational age, and birth weight-for-gestational age. AHRR DNA methylation was positively associated with maternal BMI (P = 0.0009) and negatively associated with the length of gestation (P < 0.0001) and birth weight-for-gestational age (P < 0.0001). AHRR DNA methylation was 2.1% higher in offspring of obese vs. normal weight mothers and 3.1% higher in preterm vs. term infants, representing a third and a half standard deviation differences in methylation, respectively. In conclusion, offspring AHRR DNA methylation was associated with maternal obesity during pregnancy as well as infant gestational age and birth weight-for-gestational age. Further work to discover the health impacts of altered AHRR DNA methylation is warranted.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Offspring
Birth weight
Aryl hydrocarbon receptor repressor
Gestational Age
Biology
Body Mass Index
Epigenesis, Genetic
Pregnancy
Internal medicine
medicine
Basic Helix-Loop-Helix Transcription Factors
Birth Weight
Humans
Epigenetics
Obesity
Molecular Biology
Mexico
Infant, Newborn
Gestational age
Infant
Methylation
DNA Methylation
medicine.disease
Fetal Blood
Repressor Proteins
Endocrinology
Prenatal Exposure Delayed Effects
DNA methylation
Female
Research Paper
Subjects
Details
- ISSN :
- 15592308
- Volume :
- 10
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Epigenetics
- Accession number :
- edsair.doi.dedup.....40d3a8c913915a8fb57a09087684defe