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Practical Physics Behind Growing Crystals of Biological Macromolecules
- Source :
- Protein and Peptide Letters, Protein and Peptide Letters, Bentham Science Publishers, 2012, 19, pp.714-724, Protein and Peptide Letters, 2012, 19, pp.714-724, HAL
- Publication Year :
- 2012
- Publisher :
- Bentham Science Publishers Ltd., 2012.
-
Abstract
- The aim of this review is to provide biocrystallographers who intend to tackle protein-crystallization with the- ory and practical examples. Crystallization involves two separate processes, nucleation and growth, which are rarely com- pletely unconnected. Here we give theoretical background and concrete examples illustrating protein crystallization. We describe the nucleation of a new phase, solid or liquid, and the growth and transformation of existing crystals obtained by primary or secondary nucleation or by seeding. Above all, we believe that a thorough knowledge of the phase diagram is vital to the selection of starting position and path for any crystallization experiment.
- Subjects :
- Biophysics
Nucleation
Crystal growth
Nanotechnology
02 engineering and technology
01 natural sciences
Biochemistry
Phase Transition
law.invention
Structural Biology
law
Phase (matter)
0103 physical sciences
Statistical physics
Crystallization
Phase diagram
010302 applied physics
Physics
Chemistry
Temperature
Proteins
General Medicine
021001 nanoscience & nanotechnology
Solubility
0210 nano-technology
Protein crystallization
Subjects
Details
- ISSN :
- 09298665
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Protein & Peptide Letters
- Accession number :
- edsair.doi.dedup.....40ca09673d6c0bfc43416b04069bc893