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Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment

Authors :
Angela Listì
Christian D. Rolfo
Francesco Passiglia
Ignacio Gil-Bazo
Luis E. Raez
Antonio Russo
Paolo Manca
Joseph A. Pinto
Simona Taverna
Elisa Giovannetti
Christian Caglevic
Passiglia, F.
Caglevic, C.
Giovannetti, E.
Pinto, JA.
Manca, P.
Taverna, S.
Listì, A.
Gil-Bazo, I.
Raez, LE.
Russo, A.
Rolfo, C.
Source :
Seminars in cancer biology, Passiglia, F, Caglevic, C, Giovannetti, E, Pinto, J A, Manca, P, Taverna, S, Listì, A, Gil-Bazo, I, Raez, L E, Russo, A & Rolfo, C 2018, ' Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment ', Seminars in Cancer Biology, vol. 52, no. Pt 2, pp. 259-268 . https://doi.org/10.1016/j.semcancer.2018.01.015
Publication Year :
2018

Abstract

Recent studies with immunomodulatory agents targeting both cytotoxic T-lymphocyte protein 4 (CTLA4) and programmed cell death 1 (PD1)/programmed cell death ligand 1 (PDL1) have shown to be very effective in several cancers revealing an unexpected great activity in patients with both primary and metastatic brain tumors. Combining anti-CTLA4 and anti-PD1 agents as upfront systemic therapy has revealed to further increase the clinical benefit observed with single agent, even at cost of higher toxicity. Since the brain is an immunological specialized area it's crucial to establish the specific composition of the brain tumors' micro environment in order to predict the potential activity of immunomodulatory agents. This review briefly summarizes the basis of the brain immunogenicity, providing the most updated clinical evidences in terms of immune-checkpoint inhibitors efficacy and toxicity in both primary and metastatic brain tumors with the final aim of defining potential biomarkers for immunomodulatory cancer treatment.

Details

Language :
English
ISSN :
1044579X
Database :
OpenAIRE
Journal :
Seminars in cancer biology
Accession number :
edsair.doi.dedup.....40b71b1dfaf531ceed0915a34a319060